Open Access
Translator Disclaimer
January, 1978 Maximum Likelihood Estimation of Dose-Response Functions Subject to Absolutely Monotonic Constraints
H. A. Guess, K. S. Crump
Ann. Statist. 6(1): 101-111 (January, 1978). DOI: 10.1214/aos/1176344069


Statistical properties are derived for maximum likelihood estimates of dose-response functions in which the response probability is related to the dose by means of a polynomial of unknown degree with nonnegative coefficients. Dose-response functions of this form are predicted by the multistage model of carcinogenesis. We first establish necessary and sufficient conditions for strong consistency of the estimates. For these results no assumptions are made about the polynomial degree, so the number of coefficients to be estimated is effectively infinite. Under some additional assumptions, which do involve restrictions on the polynomial degree, we obtain the asymptotic distribution of the vector of maximum likelihood estimates about the true vector of polynomial coefficients. Because the coefficients are constrained to be nonnegative, the limiting distribution will generally not be normal.


Download Citation

H. A. Guess. K. S. Crump. "Maximum Likelihood Estimation of Dose-Response Functions Subject to Absolutely Monotonic Constraints." Ann. Statist. 6 (1) 101 - 111, January, 1978.


Published: January, 1978
First available in Project Euclid: 12 April 2007

zbMATH: 0371.62147
MathSciNet: MR458771
Digital Object Identifier: 10.1214/aos/1176344069

Primary: 62P10
Secondary: 60F15 , 62E20

Keywords: Absolutely monotonic functions , cancer risk estimation , constrained maximum likelihood estimates , Convergence in distribution , dose-response functions , strong consistency , Tchebycheff systems

Rights: Copyright © 1978 Institute of Mathematical Statistics


Vol.6 • No. 1 • January, 1978
Back to Top