Open Access
January, 1978 The Adaptive Biased Coin Design for Sequential Experiments
L. J. Wei
Ann. Statist. 6(1): 92-100 (January, 1978). DOI: 10.1214/aos/1176344068


In comparing two treatments, eligible subjects come to the experiment sequentially and must be treated at once. To reduce experimental bias and to increase the precision of inference about treatment effects, the adaptive biased coin design, which offers a compromise between perfect balance and complete randomization, is proposed and analyzed. This new design has the property that it forces a small-sized experiment to be balanced, but tends toward the complete randomization scheme as the size of the experiment increases.


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L. J. Wei. "The Adaptive Biased Coin Design for Sequential Experiments." Ann. Statist. 6 (1) 92 - 100, January, 1978.


Published: January, 1978
First available in Project Euclid: 12 April 2007

zbMATH: 0374.62075
MathSciNet: MR471205
Digital Object Identifier: 10.1214/aos/1176344068

Primary: 62L05
Secondary: 60K30

Keywords: balance randomization , biased coin design , clinical trial , experimental bias , Sequential experiment

Rights: Copyright © 1978 Institute of Mathematical Statistics

Vol.6 • No. 1 • January, 1978
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