December 2022 Rerandomization with diminishing covariate imbalance and diverging number of covariates
Yuhao Wang, Xinran Li
Author Affiliations +
Ann. Statist. 50(6): 3439-3465 (December 2022). DOI: 10.1214/22-AOS2235

Abstract

Completely randomized experiments have been the gold standard for drawing causal inference because they can balance all potential confounding on average. However, they may suffer from unbalanced covariates for realized treatment assignments. Rerandomization, a design that rerandomizes the treatment assignment until a prespecified covariate balance criterion is met, has recently got attention due to its easy implementation, improved covariate balance and more efficient inference. Researchers have then suggested to use the treatment assignments that minimize the covariate imbalance, namely the optimally balanced design. This has caused again the long-time controversy between two philosophies for designing experiments: randomization versus optimal, and thus almost deterministic designs. Existing literature argued that rerandomization with overly balanced observed covariates can lead to highly imbalanced unobserved covariates, making it vulnerable to model misspecification. On the contrary, rerandomization with properly balanced covariates can provide robust inference for treatment effects while sacrificing some efficiency compared to the ideally optimal design. In this paper, we show it is possible that, by making the covariate imbalance diminishing at a proper rate as the sample size increases, rerandomization can achieve its ideally optimal precision that one can expect with perfectly balanced covariates, while still maintaining its robustness. We further investigate conditions on the number of covariates for achieving the desired optimality. Our results rely on a more delicate asymptotic analysis for rerandomization, allowing both diminishing covariate imbalance threshold (or equivalently the acceptance probability) and diverging number of covariates. The derived theory for rerandomization provides a deeper understanding of its large-sample property and can better guide its practical implementation. Furthermore, it also helps reconcile the controversy between randomized and optimal designs in an asymptotic sense.

Funding Statement

The work of Yuhao Wang was supported by Tsinghua New Faculty Start-up Fund and the 2030 Innovation Megaprojects of China (Programme on New Generation Artificial Intelligence) Grant No. 2021AAA0150000.

Acknowledgments

We thank the Editor, the Associate Editor and three reviewers for constructive comments.

Yuhao Wang is also affiliated with Shanghai Qi Zhi Institute.

Citation

Download Citation

Yuhao Wang. Xinran Li. "Rerandomization with diminishing covariate imbalance and diverging number of covariates." Ann. Statist. 50 (6) 3439 - 3465, December 2022. https://doi.org/10.1214/22-AOS2235

Information

Received: 1 April 2022; Revised: 1 July 2022; Published: December 2022
First available in Project Euclid: 21 December 2022

MathSciNet: MR4524503
zbMATH: 07641132
Digital Object Identifier: 10.1214/22-AOS2235

Subjects:
Primary: 62K99
Secondary: 62K05

Keywords: Berry–Esseen bound , Causal inference , High-dimensional covariates , Mahalanobis distance , optimal rerandomization

Rights: Copyright © 2022 Institute of Mathematical Statistics

Vol.50 • No. 6 • December 2022
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