In regression analysis with repeated measurements, such as longitudinal data and panel data, structured covariance matrices characterized by a small number of parameters have been widely used and play an important role in parameter estimation and statistical inference. To assess the adequacy of a specified covariance structure, one often adopts the classical likelihood-ratio test when the dimension of the repeated measurements ($p$) is smaller than the sample size ($n$). However, this assessment becomes quite challenging when $p$ is bigger than $n$, since the classical likelihood-ratio test is no longer applicable. This paper proposes an adjusted goodness-of-fit test to examine a broad range of covariance structures under the scenario of “large $p$, small $n$.” Analytical examples are presented to illustrate the effectiveness of the adjustment. In addition, large sample properties of the proposed test are established. Moreover, simulation studies and a real data example are provided to demonstrate the finite sample performance and the practical utility of the test.
"Tests for covariance structures with high-dimensional repeated measurements." Ann. Statist. 45 (3) 1185 - 1213, June 2017. https://doi.org/10.1214/16-AOS1481