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August 2006 Discussion of “Equi-energy sampler” by Kou, Zhou and Wong
Peter Minary, Michael Levitt
Ann. Statist. 34(4): 1636-1641 (August 2006). DOI: 10.1214/009053606000000470


Novel sampling algorithms can significantly impact open questions in computational biology, most notably the in silico protein folding problem. By using computational methods, protein folding aims to find the three-dimensional structure of a protein chain given the sequence of its amino acid building blocks. The complexity of the problem strongly depends on the protein representation and its energy function. The more detailed the model, the more complex its corresponding energy function and the more challenge it sets for sampling algorithms. Kou, Zhou and Wong have introduced a novel sampling method, which could contribute significantly to the field of structural prediction.


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Peter Minary. Michael Levitt. "Discussion of “Equi-energy sampler” by Kou, Zhou and Wong." Ann. Statist. 34 (4) 1636 - 1641, August 2006.


Published: August 2006
First available in Project Euclid: 3 November 2006

zbMATH: 1246.82055
MathSciNet: MR2283711
Digital Object Identifier: 10.1214/009053606000000470

Rights: Copyright © 2006 Institute of Mathematical Statistics

Vol.34 • No. 4 • August 2006
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