Open Access
March 2015 Inferring network structure from interventional time-course experiments
Simon E. F. Spencer, Steven M. Hill, Sach Mukherjee
Ann. Appl. Stat. 9(1): 507-524 (March 2015). DOI: 10.1214/15-AOAS806


Graphical models are widely used to study biological networks. Interventions on network nodes are an important feature of many experimental designs for the study of biological networks. In this paper we put forward a causal variant of dynamic Bayesian networks (DBNs) for the purpose of modeling time-course data with interventions. The models inherit the simplicity and computational efficiency of DBNs but allow interventional data to be integrated into network inference. We show empirical results, on both simulated and experimental data, that demonstrate the need to appropriately handle interventions when interventions form part of the design.


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Simon E. F. Spencer. Steven M. Hill. Sach Mukherjee. "Inferring network structure from interventional time-course experiments." Ann. Appl. Stat. 9 (1) 507 - 524, March 2015.


Published: March 2015
First available in Project Euclid: 28 April 2015

zbMATH: 06446578
MathSciNet: MR3341125
Digital Object Identifier: 10.1214/15-AOAS806

Keywords: Bayesian inference , causal Bayesian network , Causal inference , dynamic Bayesian network , Network inference , structure learning

Rights: Copyright © 2015 Institute of Mathematical Statistics

Vol.9 • No. 1 • March 2015
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