Translator Disclaimer
December 2019 Objective Bayes model selection of Gaussian interventional essential graphs for the identification of signaling pathways
Federico Castelletti, Guido Consonni
Ann. Appl. Stat. 13(4): 2289-2311 (December 2019). DOI: 10.1214/19-AOAS1275

Abstract

A signalling pathway is a sequence of chemical reactions initiated by a stimulus which in turn affects a receptor, and then through some intermediate steps cascades down to the final cell response. Based on the technique of flow cytometry, samples of cell-by-cell measurements are collected under each experimental condition, resulting in a collection of interventional data (assuming no latent variables are involved). Usually several external interventions are applied at different points of the pathway, the ultimate aim being the structural recovery of the underlying signalling network which we model as a causal Directed Acyclic Graph (DAG) using intervention calculus. The advantage of using interventional data, rather than purely observational one, is that identifiability of the true data generating DAG is enhanced. More technically a Markov equivalence class of DAGs, whose members are statistically indistinguishable based on observational data alone, can be further decomposed, using additional interventional data, into smaller distinct Interventional Markov equivalence classes. We present a Bayesian methodology for structural learning of Interventional Markov equivalence classes based on observational and interventional samples of multivariate Gaussian observations. Our approach is objective, meaning that it is based on default parameter priors requiring no personal elicitation; some flexibility is however allowed through a tuning parameter which regulates sparsity in the prior on model space. Based on an analytical expression for the marginal likelihood of a given Interventional Essential Graph, and a suitable MCMC scheme, our analysis produces an approximate posterior distribution on the space of Interventional Markov equivalence classes, which can be used to provide uncertainty quantification for features of substantive scientific interest, such as the posterior probability of inclusion of selected edges, or paths.

Citation

Download Citation

Federico Castelletti. Guido Consonni. "Objective Bayes model selection of Gaussian interventional essential graphs for the identification of signaling pathways." Ann. Appl. Stat. 13 (4) 2289 - 2311, December 2019. https://doi.org/10.1214/19-AOAS1275

Information

Received: 1 April 2018; Revised: 1 February 2019; Published: December 2019
First available in Project Euclid: 28 November 2019

zbMATH: 07160940
MathSciNet: MR4037431
Digital Object Identifier: 10.1214/19-AOAS1275

Keywords: Causal inference , Graphical model , Markov equivalence class

Rights: Copyright © 2019 Institute of Mathematical Statistics

JOURNAL ARTICLE
23 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
Vol.13 • No. 4 • December 2019
Back to Top