Journal of Applied Mathematics

A Hybrid Cellular Automata Model of Multicellular Tumour Spheroid Growth in Hypoxic Microenvironment

Yan Cai, Jie Wu, Shixiong Xu, and Zhiyong Li

Full-text: Open access

Abstract

A three-dimensional hybrid cellular automata (CA) model is developed to study the dynamic process of multicellular tumour spheroid (MTS) growth by introducing hypoxia as an important microenvironment factor which influences cell migration and cell phenotype expression. The model enables us to examine the effects of different hypoxic environments on the growth history of the MTS and to study the dynamic interactions between MTS growth and chemical environments. The results include the spatial distribution of different phenotypes of tumour cells and associated oxygen concentration distributions under hypoxic conditions. The discussion of the model system responses to the varied hypoxic conditions reveals that the improvement of the resistance of tumour cells to a hypoxic environment may be important in the tumour normalization therapy.

Article information

Source
J. Appl. Math., Volume 2013 (2013), Article ID 519895, 10 pages.

Dates
First available in Project Euclid: 14 March 2014

Permanent link to this document
https://projecteuclid.org/euclid.jam/1394807873

Digital Object Identifier
doi:10.1155/2013/519895

Zentralblatt MATH identifier
1266.68134

Citation

Cai, Yan; Wu, Jie; Xu, Shixiong; Li, Zhiyong. A Hybrid Cellular Automata Model of Multicellular Tumour Spheroid Growth in Hypoxic Microenvironment. J. Appl. Math. 2013 (2013), Article ID 519895, 10 pages. doi:10.1155/2013/519895. https://projecteuclid.org/euclid.jam/1394807873


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