Analysis of proteomics data: Block $k$-mean alignment

Mara Bernardi; Laura M. Sangalli; Piercesare Secchi; Simone Vantini

doi:10.1214/14-EJS900A

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Home > Journals > Electron. J. Statist. > Volume 8 > Issue 2 > Article

2014 Analysis of proteomics data: Block

k

-mean alignment

Mara Bernardi, Laura M. Sangalli, Piercesare Secchi, Simone Vantini

Electron. J. Statist. 8(2): 1714-1723 (2014). DOI: 10.1214/14-EJS900A

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Abstract

We analyze the proteomics data introducing a block $k$ -mean alignment procedure. This technique is able to jointly align and cluster the data, accounting appropriately for the block structure of these data, that includes measurement repetitions for each patient. An analysis of area-under-peaks, following the alignment, separates patients who respond and those who do not respond to treatment.

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Mara Bernardi. Laura M. Sangalli. Piercesare Secchi. Simone Vantini. "Analysis of proteomics data: Block $k$ -mean alignment." Electron. J. Statist. 8 (2) 1714 - 1723, 2014. https://doi.org/10.1214/14-EJS900A