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August, 1988 Statistical Aspects of Using Biologic Markers
Barry H. Margolin
Statist. Sci. 3(3): 351-357 (August, 1988). DOI: 10.1214/ss/1177012837


This expository paper surveys a variety of statistical issues pertinent to the design and analysis of studies involving biologic markers of human genotoxic exposure. Examples with cytogenetic and mutagenic end points are presented. One principal theme is the valuable interplay of ideas among statistical analyses for in vitro, in vivo and human assays for genetic toxicity; e.g., statistical analysis of sister chromatid exchanges in vitro is suggestive of an analytical approach to the study of sister chromatid exchanges in humans. Other topics discussed include (i) combining information from a series of studies of a common suspect genotoxic exposure and (ii) the utility of historical control information.


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Barry H. Margolin. "Statistical Aspects of Using Biologic Markers." Statist. Sci. 3 (3) 351 - 357, August, 1988.


Published: August, 1988
First available in Project Euclid: 19 April 2007

Digital Object Identifier: 10.1214/ss/1177012837

Rights: Copyright © 1988 Institute of Mathematical Statistics


Vol.3 • No. 3 • August, 1988
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