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2012 Nonlinearities in Drug Release Process from Polymeric Microparticles: Long-Time-Scale Behaviour
Elena Simona Bacaita, Costica Bejinariu, Borsos Zoltan, Catalina Peptu, Gabriela Andrei, Marcel Popa, Daniela Magop, Maricel Agop
J. Appl. Math. 2012(SI10): 1-26 (2012). DOI: 10.1155/2012/653720


A theoretical model of the drug release process from polymeric microparticles (a particular type of polymer matrix), through dispersive fractal approximation of motion, is built. As a result, the drug release process takes place through cnoidal oscillations modes of a normalized concentration field. This indicates that, in the case of long-time-scale evolutions, the drug particles assemble in a lattice of nonlinear oscillators occur macroscopically, through variations of drug concentration. The model is validated by experimental results.


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Elena Simona Bacaita. Costica Bejinariu. Borsos Zoltan. Catalina Peptu. Gabriela Andrei. Marcel Popa. Daniela Magop. Maricel Agop. "Nonlinearities in Drug Release Process from Polymeric Microparticles: Long-Time-Scale Behaviour." J. Appl. Math. 2012 (SI10) 1 - 26, 2012.


Published: 2012
First available in Project Euclid: 3 January 2013

Digital Object Identifier: 10.1155/2012/653720

Rights: Copyright © 2012 Hindawi

Vol.2012 • No. SI10 • 2012
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