We develop fast algorithms for computing the linking number of a simplicial complex within a filtration. We give experimental results in applying our work toward the detection of non-trivial tangling in biomolecules, modeled as alpha complexes.
Herbert Edelsbrunner. Afra Zomorodian. "Computing linking numbers of a filtration." Homology Homotopy Appl. 5 (2) 19 - 37, 2003.