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March 2010 A Bayesian image analysis of radiation induced changes in tumor vascular permeability
Yue Cao, Timothy D. Johnson, Roderick J. A. Little, Xiaoxi Zhang
Bayesian Anal. 5(1): 189-212 (March 2010). DOI: 10.1214/10-BA508


This work is motivated by a quantitative Magnetic Resonance Imaging study of the relative change in tumor vascular permeability during the course of radiation therapy. The differences in tumor and healthy brain tissue physiology and pathology constitute a notable feature of the image data---spatial heterogeneity with respect to its contrast uptake profile (a surrogate for permeability) and radiation induced changes in this profile. To account for these spatial aspects of the data, we employ a Gaussian hidden Markov random field (MRF) model. The model incorporates a latent set of discrete labels from the MRF governed by a spatial regularization parameter. We estimate the MRF regularization parameter and treat the number of MRF states as a random variable and estimate it via a reversible jump Markov chain Monte Carlo algorithm. We conduct simulation studies to examine the performance of the model and compare it with a recently proposed method using the Expectation-Maximization (EM) algorithm. Simulation results show that the Bayesian algorithm performs as well, if not slightly better than the EM based algorithm. Results on real data suggest that the tumor "core" vascular permeability increases relative to healthy tissue three weeks after starting radiotherapy, which may be an opportune time to initiate chemotherapy and warrants further investigation.


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Yue Cao. Timothy D. Johnson. Roderick J. A. Little. Xiaoxi Zhang. "A Bayesian image analysis of radiation induced changes in tumor vascular permeability." Bayesian Anal. 5 (1) 189 - 212, March 2010.


Published: March 2010
First available in Project Euclid: 22 June 2012

zbMATH: 1330.62267
MathSciNet: MR2596441
Digital Object Identifier: 10.1214/10-BA508

Keywords: Hidden Markov random fields , image analysis , Mann Whitney U statistic , Quantitative Magnetic Resonance Imaging , quantitative MRI , reversible jump MCMC , Swendsen-Wang algorithm

Rights: Copyright © 2010 International Society for Bayesian Analysis


Vol.5 • No. 1 • March 2010
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