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March, 1993 A Sequential Clinical Trial for Comparing Three Treatments
D. Siegmund
Ann. Statist. 21(1): 464-483 (March, 1993). DOI: 10.1214/aos/1176349037

Abstract

A model for sequential clinical trials involving three treatments is proposed and various error probabilities are defined. A specific procedure involving a concatenation of repeated significance tests is studied in detail. The first phase of testing proceeds until at least one treatment is eliminated; and then a second phase is used to compare the remaining treatments. Analytic approximations to the operating characteristics of the test are derived and compared with the results of a Monte Carlo experiment.

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D. Siegmund. "A Sequential Clinical Trial for Comparing Three Treatments." Ann. Statist. 21 (1) 464 - 483, March, 1993. https://doi.org/10.1214/aos/1176349037

Information

Published: March, 1993
First available in Project Euclid: 12 April 2007

zbMATH: 0770.62065
MathSciNet: MR1212188
Digital Object Identifier: 10.1214/aos/1176349037

Subjects:
Primary: 62L10
Secondary: 62N10

Rights: Copyright © 1993 Institute of Mathematical Statistics

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Vol.21 • No. 1 • March, 1993
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