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December 2015 Lymphangiogenesis and carcinoma in the uterine cervix: Joint and hierarchical models for random cluster sizes and continuous outcomes
T. R. Fanshawe, C. M. Chapman, T. Crick
Ann. Appl. Stat. 9(4): 1932-1949 (December 2015). DOI: 10.1214/15-AOAS867

Abstract

Although the lymphatic system is clearly linked to the metastasis of most human carcinomas, the mechanisms by which lymphangiogenesis occurs in response to the presence of carcinoma remain unclear. Hierarchical models are presented to investigate the properties of lymphatic vessel production in 2997 fields taken from 20 individuals with invasive carcinoma, 21 individuals with cervical intraepithelial neoplasia and 21 controls. Such data demonstrate a high degree of correlation within tumour samples from the same individual. Joint hierarchical models utilising shared random effects are discussed and fitted in a Bayesian framework to allow for the correlation between two key outcome measures: a random cluster size (the number of lymphatic vessels in a tissue sample) and a continuous outcome (vessel size). Results show that invasive carcinoma samples are associated with increased production of smaller and more irregularly-shaped lymphatic vessels and suggest a mechanistic link between carcinoma of the cervix and lymphangiogenesis.

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T. R. Fanshawe. C. M. Chapman. T. Crick. "Lymphangiogenesis and carcinoma in the uterine cervix: Joint and hierarchical models for random cluster sizes and continuous outcomes." Ann. Appl. Stat. 9 (4) 1932 - 1949, December 2015. https://doi.org/10.1214/15-AOAS867

Information

Received: 1 June 2013; Revised: 1 July 2014; Published: December 2015
First available in Project Euclid: 28 January 2016

zbMATH: 06560815
MathSciNet: MR3456359
Digital Object Identifier: 10.1214/15-AOAS867

Keywords: Cervical carcinoma , hierarchical model , informative cluster size , joint model , lymphangiogenesis , random effect

Rights: Copyright © 2015 Institute of Mathematical Statistics

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Vol.9 • No. 4 • December 2015
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