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September 2014 Bayesian sparse graphical models for classification with application to protein expression data
Veerabhadran Baladandayuthapani, Rajesh Talluri, Yuan Ji, Kevin R. Coombes, Yiling Lu, Bryan T. Hennessy, Michael A. Davies, Bani K. Mallick
Ann. Appl. Stat. 8(3): 1443-1468 (September 2014). DOI: 10.1214/14-AOAS722


Reverse-phase protein array (RPPA) analysis is a powerful, relatively new platform that allows for high-throughput, quantitative analysis of protein networks. One of the challenges that currently limit the potential of this technology is the lack of methods that allow for accurate data modeling and identification of related networks and samples. Such models may improve the accuracy of biological sample classification based on patterns of protein network activation and provide insight into the distinct biological relationships underlying different types of cancer. Motivated by RPPA data, we propose a Bayesian sparse graphical modeling approach that uses selection priors on the conditional relationships in the presence of class information. The novelty of our Bayesian model lies in the ability to draw information from the network data as well as from the associated categorical outcome in a unified hierarchical model for classification. In addition, our method allows for intuitive integration of a priori network information directly in the model and allows for posterior inference on the network topologies both within and between classes. Applying our methodology to an RPPA data set generated from panels of human breast cancer and ovarian cancer cell lines, we demonstrate that the model is able to distinguish the different cancer cell types more accurately than several existing models and to identify differential regulation of components of a critical signaling network (the PI3K-AKT pathway) between these two types of cancer. This approach represents a powerful new tool that can be used to improve our understanding of protein networks in cancer.


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Veerabhadran Baladandayuthapani. Rajesh Talluri. Yuan Ji. Kevin R. Coombes. Yiling Lu. Bryan T. Hennessy. Michael A. Davies. Bani K. Mallick. "Bayesian sparse graphical models for classification with application to protein expression data." Ann. Appl. Stat. 8 (3) 1443 - 1468, September 2014.


Published: September 2014
First available in Project Euclid: 23 October 2014

zbMATH: 1303.62057
MathSciNet: MR3271339
Digital Object Identifier: 10.1214/14-AOAS722

Keywords: Bayesian methods , graphical models , Mixture models , protein signaling pathways

Rights: Copyright © 2014 Institute of Mathematical Statistics


Vol.8 • No. 3 • September 2014
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