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March 2009 Modeling substitution and indel processes for AFLP marker evolution and phylogenetic inference
Ruiyan Luo, Bret Larget
Ann. Appl. Stat. 3(1): 222-248 (March 2009). DOI: 10.1214/08-AOAS212

Abstract

The amplified fragment length polymorphism (AFLP) method produces anonymous genetic markers from throughout a genome. We extend the nucleotide substitution model of AFLP evolution to additionally include insertion and deletion processes. The new Sub-ID model relaxes the common assumption that markers are independent and homologous. We build a Markov chain Monte Carlo methodology tailored for the Sub-ID model to implement a Bayesian approach to infer AFLP marker evolution. The method allows us to infer both the phylogenies and the subset of markers that are possibly homologous. In addition, we can infer the genome-wide relative rate of indels versus substitutions. In a case study with AFLP markers from sedges, a grass-like plant common in North America, we find that accounting for insertion and deletion makes a difference in phylogenetic inference. The inference of topologies is not sensitive to the prior settings and the Jukes–Cantor assumption for nucleotide substitution. The model for insertion and deletion we introduce has potential value in other phylogenetic applications.

Citation

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Ruiyan Luo. Bret Larget. "Modeling substitution and indel processes for AFLP marker evolution and phylogenetic inference." Ann. Appl. Stat. 3 (1) 222 - 248, March 2009. https://doi.org/10.1214/08-AOAS212

Information

Published: March 2009
First available in Project Euclid: 16 April 2009

zbMATH: 1160.62091
MathSciNet: MR2668706
Digital Object Identifier: 10.1214/08-AOAS212

Keywords: Amplified fragment length polymorphism , insertion and deletion , Markov chain Monte Carlo , phylogeny , statistical phylogenetics

Rights: Copyright © 2009 Institute of Mathematical Statistics

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Vol.3 • No. 1 • March 2009
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