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June 2017 Bayesian inference of high-dimensional, cluster-structured ordinary differential equation models with applications to brain connectivity studies
Tingting Zhang, Qiannan Yin, Brian Caffo, Yinge Sun, Dana Boatman-Reich
Ann. Appl. Stat. 11(2): 868-897 (June 2017). DOI: 10.1214/17-AOAS1021

Abstract

We build a new ordinary differential equation (ODE) model for the directional interaction, also called effective connectivity, among brain regions whose activities are measured by intracranial electrocorticography (ECoG) data. In contrast to existing ODE models that focus on effective connectivity among only a few large anatomic brain regions and that rely on strong prior belief of the existence and strength of the connectivity, the proposed high-dimensional ODE model, motivated by statistical considerations, can be used to explore connectivity among multiple small brain regions. The new model, called the modular and indicator-based dynamic directional model (MIDDM), features a cluster structure, which consists of modules of densely connected brain regions, and uses indicators to differentiate significant and void directional interactions among brain regions. We develop a unified Bayesian framework to quantify uncertainty in the assumed ODE model, identify clusters, select strongly connected brain regions, and make statistical comparison between brain networks across different experimental trials. The prior distributions in the Bayesian model for MIDDM parameters are carefully designed such that the ensuing joint posterior distributions for ODE state functions and the MIDDM parameters have well-defined and easy-to-simulate posterior conditional distributions. To further speed up the posterior simulation, we employ parallel computing schemes in Markov chain Monte Carlo steps. We show that the proposed Bayesian approach outperforms an existing optimization-based ODE estimation method. We apply the proposed method to an auditory electrocorticography dataset and evaluate brain auditory network changes across trials and different auditory stimuli.

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Tingting Zhang. Qiannan Yin. Brian Caffo. Yinge Sun. Dana Boatman-Reich. "Bayesian inference of high-dimensional, cluster-structured ordinary differential equation models with applications to brain connectivity studies." Ann. Appl. Stat. 11 (2) 868 - 897, June 2017. https://doi.org/10.1214/17-AOAS1021

Information

Received: 1 June 2016; Revised: 1 January 2017; Published: June 2017
First available in Project Euclid: 20 July 2017

zbMATH: 06775896
MathSciNet: MR3693550
Digital Object Identifier: 10.1214/17-AOAS1021

Keywords: Bayesian inference , cluster structure , directional brain networks , network edge selection , ODE models

Rights: Copyright © 2017 Institute of Mathematical Statistics

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Vol.11 • No. 2 • June 2017
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