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Sequential nonparametrics and semiparametrics: Theory, implementation and applications to clinical trials

Tze Leung Lai and Zheng Su

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One of Pranab K. Sen’s major research areas is sequential nonparametrics and semiparametrics and their applications to clinical trials, to which he has made many important contributions. Herein we review a number of these contributions and related developments. We also describe some recent work on nonparametric and semiparametric inference and the associated computational methods in time-sequential clinical trials with survival endpoints.

Chapter information

N. Balakrishnan, Edsel A. Peña and Mervyn J. Silvapulle, eds., Beyond Parametrics in Interdisciplinary Research: Festschrift in Honor of Professor Pranab K. Sen (Beachwood, Ohio, USA: Institute of Mathematical Statistics, 2008), 332-349

First available in Project Euclid: 1 April 2008

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Primary: 62L10: Sequential analysis 62G10: Hypothesis testing
Secondary: 62N02: Estimation

clinical trials nonparametrics semiparametrics survival analysis

Copyright © 2008, Institute of Mathematical Statistics


Lai, Tze Leung; Su, Zheng. Sequential nonparametrics and semiparametrics: Theory, implementation and applications to clinical trials. Beyond Parametrics in Interdisciplinary Research: Festschrift in Honor of Professor Pranab K. Sen, 332--349, Institute of Mathematical Statistics, Beachwood, Ohio, USA, 2008. doi:10.1214/193940307000000257.

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