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August, 1994 Sequence Comparison Significance and Poisson Approximation
Michael S. Waterman, Martin Vingron
Statist. Sci. 9(3): 367-381 (August, 1994). DOI: 10.1214/ss/1177010382

Abstract

The Chen-Stein method of Poisson approximation has been used to establish theorems about comparison of two DNA or protein sequences. The most useful result for sequence alignment applies to alignment scoring with no gaps. However, there has not been a valid method to assign statistical significance to alignment scores with gaps. In this paper we extend Poisson approximation techniques using the Aldous clumping heuristic to a practical method of estimating statistical significance.

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Michael S. Waterman. Martin Vingron. "Sequence Comparison Significance and Poisson Approximation." Statist. Sci. 9 (3) 367 - 381, August, 1994. https://doi.org/10.1214/ss/1177010382

Information

Published: August, 1994
First available in Project Euclid: 19 April 2007

zbMATH: 0955.92501
MathSciNet: MR1325433
Digital Object Identifier: 10.1214/ss/1177010382

Rights: Copyright © 1994 Institute of Mathematical Statistics

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Vol.9 • No. 3 • August, 1994
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