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August, 1990 Statistical Approaches to Interim Monitoring of Medical Trials: A Review and Commentary
Christopher Jennison, Bruce W. Turnbull
Statist. Sci. 5(3): 299-317 (August, 1990). DOI: 10.1214/ss/1177012099

Abstract

Most medical trials are monitored for early evidence of treatment differences or harmful side effects. In this paper we review and critique various statistical approaches that have been proposed for the design and analysis of sequential experiments in medical applications. We discuss group sequential tests, stochastic curtailment, repeated confidence intervals, and Bayesian procedures. The role that a statistical stopping rule should play in the final analysis is examined.

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Christopher Jennison. Bruce W. Turnbull. "Statistical Approaches to Interim Monitoring of Medical Trials: A Review and Commentary." Statist. Sci. 5 (3) 299 - 317, August, 1990. https://doi.org/10.1214/ss/1177012099

Information

Published: August, 1990
First available in Project Euclid: 19 April 2007

zbMATH: 0955.62640
MathSciNet: MR1080954
Digital Object Identifier: 10.1214/ss/1177012099

Rights: Copyright © 1990 Institute of Mathematical Statistics

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Vol.5 • No. 3 • August, 1990
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