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May 2010 Continual Reassessment and Related Dose-Finding Designs
John O’Quigley, Mark Conaway
Statist. Sci. 25(2): 202-216 (May 2010). DOI: 10.1214/10-STS332


During the last twenty years there have been considerable methodological developments in the design and analysis of Phase 1, Phase 2 and Phase 1/2 dose-finding studies. Many of these developments are related to the continual reassessment method (CRM), first introduced by O’Quigley, Pepe and Fisher (1990). CRM models have proven themselves to be of practical use and, in this discussion, we investigate the basic approach, some connections to other methods, some generalizations, as well as further applications of the model. We obtain some new results which can provide guidance in practice.


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John O’Quigley. Mark Conaway. "Continual Reassessment and Related Dose-Finding Designs." Statist. Sci. 25 (2) 202 - 216, May 2010.


Published: May 2010
First available in Project Euclid: 19 November 2010

zbMATH: 1328.62594
MathSciNet: MR2789990
Digital Object Identifier: 10.1214/10-STS332

Rights: Copyright © 2010 Institute of Mathematical Statistics


Vol.25 • No. 2 • May 2010
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