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November 2009 The Role of Family-Based Designs in Genome-Wide Association Studies
Nan M. Laird, Christoph Lange
Statist. Sci. 24(4): 388-397 (November 2009). DOI: 10.1214/08-STS280

Abstract

Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs. Family-based association designs have long been attractive for their robustness properties, but robustness can mean a loss of power. In this paper we discuss some of the special features of family designs and their relevance in the era of GWAS.

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Nan M. Laird. Christoph Lange. "The Role of Family-Based Designs in Genome-Wide Association Studies." Statist. Sci. 24 (4) 388 - 397, November 2009. https://doi.org/10.1214/08-STS280

Information

Published: November 2009
First available in Project Euclid: 20 April 2010

zbMATH: 1329.62430
MathSciNet: MR2779333
Digital Object Identifier: 10.1214/08-STS280

Rights: Copyright © 2009 Institute of Mathematical Statistics

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Vol.24 • No. 4 • November 2009
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