Model Geometry for HIV-1 and -2

Abstract

A model geometry for the HIV-1 and -2 viruses is proposed based on electron microscopic observations. Standard geometric shapes are employed to describe the surface membrane, stalk (glycoprotein 41), and knob (glycoprotein 120) of the virus. Based on approximate dimensions for certain features of the virus estimates are provided for viral surface area and volume in both budding and mature stages, stalk-knob assembly surface area and volume, surface membrane area, surface membrane radius, and the ratio for surface area in the budding and mature virus. Such estimates may be useful in the quest for compounds that inhibit virus replication.