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2018 A Dynamic Model of PI3K/AKT Pathways in Acute Myeloid Leukemia
Yudi Ari Adi, Fajar Adi-Kusumo, Lina Aryati, Mardiah S. Hardianti
J. Appl. Math. 2018: 1-9 (2018). DOI: 10.1155/2018/2983138


Acute myeloid leukemia (AML) is a malignant hematopoietic disorder characterized by uncontrolled proliferation of immature myeloid cells. In the AML cases, the phosphoinositide 3-kinases (PI3K)/AKT signaling pathways are frequently activated and strongly contribute to proliferation and survival of these cells. In this paper, a mathematical model of the PI3K/AKT signaling pathways in AML is constructed to study the dynamics of the proteins in these pathways. The model is a 5-dimensional system of the first-order ODE which describes the interaction of the proteins in AML. The interactions between those components are assumed to follow biochemical reactions, which are modelled by Hill’s equation. From the numerical simulations, there are three potential components targets in PI3K/AKT pathways to therapy in the treatment of AML patient.


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Yudi Ari Adi. Fajar Adi-Kusumo. Lina Aryati. Mardiah S. Hardianti. "A Dynamic Model of PI3K/AKT Pathways in Acute Myeloid Leukemia." J. Appl. Math. 2018 1 - 9, 2018.


Received: 28 June 2018; Revised: 10 October 2018; Accepted: 5 November 2018; Published: 2018
First available in Project Euclid: 14 December 2018

zbMATH: 07051361
MathSciNet: MR3879348
Digital Object Identifier: 10.1155/2018/2983138

Rights: Copyright © 2018 Hindawi


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