Dynamic of a TB-HIV Coinfection Epidemic Model with Latent Age

Abstract

A coepidemic arises when the spread of one infectious disease stimulates the spread of another infectious disease. Recently, this has happened with human immunodeficiency virus (HIV) and tuberculosis (TB). The density of individuals infected with latent tuberculosis is structured by age since latency. The host population is divided into five subclasses of susceptibles, latent TB, active TB (without HIV), HIV infectives (without TB), and coinfection class (infected by both TB and HIV). The model exhibits three boundary equilibria, namely, disease free equilibrium, TB dominated equilibrium, and HIV dominated equilibrium. We discuss the local or global stabilities of boundary equilibria. We prove the persistence of our model. Our simple model of two synergistic infectious disease epidemics illustrates the importance of including the effects of each disease on the transmission and progression of the other disease. We simulate the dynamic behaviors of our model and give medicine explanations.