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February 1997 Information and the clone mapping of chromosomes
Bin Yu, T. P. Speed
Ann. Statist. 25(1): 169-185 (February 1997). DOI: 10.1214/aos/1034276625


A clone map of part or all of a chromosome is the result of organizing order and overlap information concerning collections of DNA fragments called clone libraries. In this paper the expected amount of information (entropy) needed to create such a map is discussed. A number of different formalizations of the notion of a clone map are considered, and exact or approximate expressions or bounds for the associated entropy are calculated for each formalization. Based on these bounds, comparisons are made for four species of the entropies associated with the mapping of their respective cosmid clone libraries. All the entropies have the same first-order term $N \log_2 N$ (when the clone library size $N \to \infty$) as that obtained by Lehrach et al.


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Bin Yu. T. P. Speed. "Information and the clone mapping of chromosomes." Ann. Statist. 25 (1) 169 - 185, February 1997.


Published: February 1997
First available in Project Euclid: 10 October 2002

zbMATH: 0876.60096
MathSciNet: MR1429921
Digital Object Identifier: 10.1214/aos/1034276625

Primary: 60K99
Secondary: 94A99

Rights: Copyright © 1997 Institute of Mathematical Statistics


Vol.25 • No. 1 • February 1997
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