Open Access
June 2018 Adjusted regularization in latent graphical models: Application to multiple-neuron spike count data
Giuseppe Vinci, Valérie Ventura, Matthew A. Smith, Robert E. Kass
Ann. Appl. Stat. 12(2): 1068-1095 (June 2018). DOI: 10.1214/18-AOAS1190


A major challenge in contemporary neuroscience is to analyze data from large numbers of neurons recorded simultaneously across many experimental replications (trials), where the data are counts of neural firing events, and one of the basic problems is to characterize the dependence structure among such multivariate counts. Methods of estimating high-dimensional covariation based on $\ell_{1}$-regularization are most appropriate when there are a small number of relatively large partial correlations, but in neural data there are often large numbers of relatively small partial correlations. Furthermore, the variation across trials is often confounded by Poisson-like variation within trials. To overcome these problems we introduce a comprehensive methodology that imbeds a Gaussian graphical model into a hierarchical structure: the counts are assumed Poisson, conditionally on latent variables that follow a Gaussian graphical model, and the graphical model parameters, in turn, are assumed to depend on physiologically-motivated covariates, which can greatly improve correct detection of interactions (nonzero partial correlations). We develop a Bayesian approach to fitting this covariate-adjusted generalized graphical model and we demonstrate its success in simulation studies. We then apply it to data from an experiment on visual attention, where we assess functional interactions between neurons recorded from two brain areas.


Download Citation

Giuseppe Vinci. Valérie Ventura. Matthew A. Smith. Robert E. Kass. "Adjusted regularization in latent graphical models: Application to multiple-neuron spike count data." Ann. Appl. Stat. 12 (2) 1068 - 1095, June 2018.


Received: 1 December 2017; Revised: 1 June 2018; Published: June 2018
First available in Project Euclid: 28 July 2018

zbMATH: 06980485
MathSciNet: MR3834295
Digital Object Identifier: 10.1214/18-AOAS1190

Keywords: Bayesian inference , Gaussian graphical models , Gaussian scale mixture , high dimensionality , Lasso , latent variable models , macaque prefrontal cortex , macaque visual cortex , Poisson-lognormal , Sparsity , spike-counts

Rights: Copyright © 2018 Institute of Mathematical Statistics

Vol.12 • No. 2 • June 2018
Back to Top