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February 2013 Population genetics of neutral mutations in exponentially growing cancer cell populations
Rick Durrett
Ann. Appl. Probab. 23(1): 230-250 (February 2013). DOI: 10.1214/11-AAP824


In order to analyze data from cancer genome sequencing projects, we need to be able to distinguish causative, or “driver,” mutations from “passenger” mutations that have no selective effect. Toward this end, we prove results concerning the frequency of neutural mutations in exponentially growing multitype branching processes that have been widely used in cancer modeling. Our results yield a simple new population genetics result for the site frequency spectrum of a sample from an exponentially growing population.


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Rick Durrett. "Population genetics of neutral mutations in exponentially growing cancer cell populations." Ann. Appl. Probab. 23 (1) 230 - 250, February 2013.


Published: February 2013
First available in Project Euclid: 25 January 2013

zbMATH: 1377.92061
MathSciNet: MR3059234
Digital Object Identifier: 10.1214/11-AAP824

Primary: 60J85 , 92D10

Keywords: cancer model , Exponentially growing population , multitype branching process , site frequency spectrum

Rights: Copyright © 2013 Institute of Mathematical Statistics

Vol.23 • No. 1 • February 2013
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