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April 2009 A waiting time problem arising from the study of multi-stage carcinogenesis
Rick Durrett, Deena Schmidt, Jason Schweinsberg
Ann. Appl. Probab. 19(2): 676-718 (April 2009). DOI: 10.1214/08-AAP559

Abstract

We consider the population genetics problem: how long does it take before some member of the population has m specified mutations? The case m=2 is relevant to onset of cancer due to the inactivation of both copies of a tumor suppressor gene. Models for larger m are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth.

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Rick Durrett. Deena Schmidt. Jason Schweinsberg. "A waiting time problem arising from the study of multi-stage carcinogenesis." Ann. Appl. Probab. 19 (2) 676 - 718, April 2009. https://doi.org/10.1214/08-AAP559

Information

Published: April 2009
First available in Project Euclid: 7 May 2009

zbMATH: 1219.92038
MathSciNet: MR2521885
Digital Object Identifier: 10.1214/08-AAP559

Subjects:
Primary: 60J99
Secondary: 60J85, 92C50, 92D25

Rights: Copyright © 2009 Institute of Mathematical Statistics

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Vol.19 • No. 2 • April 2009
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