Statistical Science

Statistical Aspects of Using Biologic Markers

Barry H. Margolin

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Abstract

This expository paper surveys a variety of statistical issues pertinent to the design and analysis of studies involving biologic markers of human genotoxic exposure. Examples with cytogenetic and mutagenic end points are presented. One principal theme is the valuable interplay of ideas among statistical analyses for in vitro, in vivo and human assays for genetic toxicity; e.g., statistical analysis of sister chromatid exchanges in vitro is suggestive of an analytical approach to the study of sister chromatid exchanges in humans. Other topics discussed include (i) combining information from a series of studies of a common suspect genotoxic exposure and (ii) the utility of historical control information.

Article information

Source
Statist. Sci., Volume 3, Number 3 (1988), 351-357.

Dates
First available in Project Euclid: 19 April 2007

Permanent link to this document
https://projecteuclid.org/euclid.ss/1177012837

Digital Object Identifier
doi:10.1214/ss/1177012837

JSTOR
links.jstor.org

Keywords
Ames Salmonella assay genetic toxicology historical control data meta-analysis Poisson dispersion test sister chromatid exchange assay

Citation

Margolin, Barry H. Statistical Aspects of Using Biologic Markers. Statist. Sci. 3 (1988), no. 3, 351--357. doi:10.1214/ss/1177012837. https://projecteuclid.org/euclid.ss/1177012837


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