International Journal of Differential Equations
- Int. J. Differ. Equ.
- Volume 2018, Special Issue (2017), Article ID 6710575, 13 pages.
Mathematical Modeling of the Adaptive Immune Responses in the Early Stage of the HBV Infection
The aim of this paper is to study the early stage of HBV infection and impact delay in the infection process on the adaptive immune response, which includes cytotoxic T-lymphocytes and antibodies. In this stage, the growth of the healthy hepatocyte cells is logistic while the growth of the infected ones is linear. To investigate the role of the treatment at this stage, we also consider two types of treatment: interferon- (IFN) and nucleoside analogues (NAs). To find the best strategy to use this treatment, an optimal control approach is developed to find the possibility of having a functional cure to HBV.
Int. J. Differ. Equ., Volume 2018, Special Issue (2017), Article ID 6710575, 13 pages.
Received: 29 August 2017
Revised: 18 November 2017
Accepted: 18 December 2017
First available in Project Euclid: 17 March 2018
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Allali, Karam; Meskaf, Adil; Tridane, Abdessamad. Mathematical Modeling of the Adaptive Immune Responses in the Early Stage of the HBV Infection. Int. J. Differ. Equ. 2018, Special Issue (2017), Article ID 6710575, 13 pages. doi:10.1155/2018/6710575. https://projecteuclid.org/euclid.ijde/1521252047