Electronic Journal of Statistics

A nonparametric HMM for genetic imputation and coalescent inference

Lloyd T. Elliott and Yee Whye Teh

Full-text: Open access

Abstract

Genetic sequence data are well described by hidden Markov models (HMMs) in which latent states correspond to clusters of similar mutation patterns. Theory from statistical genetics suggests that these HMMs are nonhomogeneous (their transition probabilities vary along the chromosome) and have large support for self transitions. We develop a new nonparametric model of genetic sequence data, based on the hierarchical Dirichlet process, which supports these self transitions and nonhomogeneity. Our model provides a parameterization of the genetic process that is more parsimonious than other more general nonparametric models which have previously been applied to population genetics. We provide truncation-free MCMC inference for our model using a new auxiliary sampling scheme for Bayesian nonparametric HMMs. In a series of experiments on male X chromosome data from the Thousand Genomes Project and also on data simulated from a population bottleneck we show the benefits of our model over the popular finite model fastPHASE, which can itself be seen as a parametric truncation of our model. We find that the number of HMM states found by our model is correlated with the time to the most recent common ancestor in population bottlenecks. This work demonstrates the flexibility of Bayesian nonparametrics applied to large and complex genetic data.

Article information

Source
Electron. J. Statist., Volume 10, Number 2 (2016), 3425-3451.

Dates
Received: January 2016
First available in Project Euclid: 16 November 2016

Permanent link to this document
https://projecteuclid.org/euclid.ejs/1479287227

Digital Object Identifier
doi:10.1214/16-EJS1197

Mathematical Reviews number (MathSciNet)
MR3572855

Zentralblatt MATH identifier
1357.62314

Subjects
Primary: 62F15: Bayesian inference
Secondary: 92D10: Genetics {For genetic algebras, see 17D92}

Keywords
Bayesian nonparametrics statistical genetics HMMs genetic imputation TMRCA inference haplotype inference population genetics

Citation

Elliott, Lloyd T.; Teh, Yee Whye. A nonparametric HMM for genetic imputation and coalescent inference. Electron. J. Statist. 10 (2016), no. 2, 3425--3451. doi:10.1214/16-EJS1197. https://projecteuclid.org/euclid.ejs/1479287227


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