Electronic Journal of Statistics

Diffusion tensor smoothing through weighted Karcher means

Owen Carmichael, Jun Chen, Debashis Paul, and Jie Peng

Full-text: Open access

Abstract

Diffusion tensor magnetic resonance imaging (MRI) quantifies the spatial distribution of water diffusion at each voxel on a regular grid of locations in a biological specimen by diffusion tensors– $3\times 3$ positive definite matrices. Removal of noise from DTI is an important problem due to the high scientific relevance of DTI and relatively low signal to noise ratio it provides. Leading approaches to this problem amount to estimation of weighted Karcher means of diffusion tensors within spatial neighborhoods, under various metrics imposed on the space of tensors. However, it is unclear how the behavior of these estimators varies with the magnitude of DTI sensor noise (the noise resulting from the thermal effects of MRI scanning) as well as the geometric structure of the underlying diffusion tensor neighborhoods. In this paper, we combine theoretical analysis, empirical analysis of simulated DTI data, and empirical analysis of real DTI scans to compare the noise removal performance of three kernel-based DTI smoothers that are based on Euclidean, log-Euclidean, and affine-invariant metrics. The results suggest, contrary to conventional wisdom, that imposing a simplistic Euclidean metric may in fact provide comparable or superior noise removal, especially in relatively unstructured regions and/or in the presence of moderate to high levels of sensor noise. On the contrary, log-Euclidean and affine-invariant metrics may lead to better noise removal in highly structured anatomical regions, especially when the sensor noise is of low magnitude. These findings emphasize the importance of considering the interplay of sensor noise magnitude and tensor field geometric structure when assessing diffusion tensor smoothing options. They also point to the necessity for continued development of smoothing methods that perform well across a large range of scenarios.

Article information

Source
Electron. J. Statist., Volume 7 (2013), 1913-1956.

Dates
Received: October 2012
First available in Project Euclid: 18 July 2013

Permanent link to this document
https://projecteuclid.org/euclid.ejs/1374153368

Digital Object Identifier
doi:10.1214/13-EJS825

Mathematical Reviews number (MathSciNet)
MR3084676

Zentralblatt MATH identifier
1293.62089

Subjects
Primary: 62G08: Nonparametric regression
Secondary: 62P10: Applications to biology and medical sciences

Keywords
Tensor space diffusion MRI Karcher mean kernel smoothing perturbation analysis

Citation

Carmichael, Owen; Chen, Jun; Paul, Debashis; Peng, Jie. Diffusion tensor smoothing through weighted Karcher means. Electron. J. Statist. 7 (2013), 1913--1956. doi:10.1214/13-EJS825. https://projecteuclid.org/euclid.ejs/1374153368


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