• Bernoulli
  • Volume 17, Number 1 (2011), 347-394.

Simultaneous critical values for t-tests in very high dimensions

Hongyuan Cao and Michael R. Kosorok

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This article considers the problem of multiple hypothesis testing using t-tests. The observed data are assumed to be independently generated conditional on an underlying and unknown two-state hidden model. We propose an asymptotically valid data-driven procedure to find critical values for rejection regions controlling the k-familywise error rate (k-FWER), false discovery rate (FDR) and the tail probability of false discovery proportion (FDTP) by using one-sample and two-sample t-statistics. We only require a finite fourth moment plus some very general conditions on the mean and variance of the population by virtue of the moderate deviations properties of t-statistics. A new consistent estimator for the proportion of alternative hypotheses is developed. Simulation studies support our theoretical results and demonstrate that the power of a multiple testing procedure can be substantially improved by using critical values directly, as opposed to the conventional p-value approach. Our method is applied in an analysis of the microarray data from a leukemia cancer study that involves testing a large number of hypotheses simultaneously.

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Bernoulli, Volume 17, Number 1 (2011), 347-394.

First available in Project Euclid: 8 February 2011

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empirical processes FDR high dimension microarrays multiple hypothesis testing one-sample t-statistics self-normalized moderate deviation two-sample t-statistics


Cao, Hongyuan; Kosorok, Michael R. Simultaneous critical values for t -tests in very high dimensions. Bernoulli 17 (2011), no. 1, 347--394. doi:10.3150/10-BEJ272.

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