Bayesian Analysis

Bayesian variable selection for probit mixed models applied to gene selection

Meli Baragatti

Full-text: Open access

Abstract

In computational biology, gene expression datasets are characterized by very few individual samples compared to a large number of measurements per sample. Thus, it is appealing to merge these datasets in order to increase the number of observations and diversify the data, allowing a more reliable selection of genes relevant to the biological problem. Besides, the increased size of a merged dataset facilitates its re-splitting into training and validation sets. This necessitates the introduction of the dataset as a random effect. In this context, extending a work of Lee et al. (2003), a method is proposed to select relevant variables among tens of thousands in a probit mixed regression model, considered as part of a larger hierarchical Bayesian model. Latent variables are used to identify subsets of selected variables and the grouping (or blocking) technique of Liu (1994) is combined with a Metropolis-within-Gibbs algorithm (Robert and Casella 2004). The method is applied to a merged dataset made of three individual gene expression datasets, in which tens of thousands of measurements are available for each of several hundred human breast cancer samples. Even for this large dataset comprised of around 20000 predictors, the method is shown to be efficient and feasible. As an illustration, it is used to select the most important genes that characterize the estrogen receptor status of patients with breast cancer.

Article information

Source
Bayesian Anal., Volume 6, Number 2 (2011), 209-229.

Dates
First available in Project Euclid: 13 June 2012

Permanent link to this document
https://projecteuclid.org/euclid.ba/1339612044

Digital Object Identifier
doi:10.1214/11-BA607

Mathematical Reviews number (MathSciNet)
MR2806242

Zentralblatt MATH identifier
1330.62297

Subjects
Primary: 62J12: Generalized linear models
Secondary: 62-04: Explicit machine computation and programs (not the theory of computation or programming) 62F15: Bayesian inference 62J07: Ridge regression; shrinkage estimators 62P10: Applications to biology and medical sciences 92D10: Genetics {For genetic algebras, see 17D92}

Keywords
Bayesian variable selection random effects probit mixed regression model grouping technique (or blocking technique) Metropolis-within-Gibbs algorithm

Citation

Baragatti, Meli. Bayesian variable selection for probit mixed models applied to gene selection. Bayesian Anal. 6 (2011), no. 2, 209--229. doi:10.1214/11-BA607. https://projecteuclid.org/euclid.ba/1339612044


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