The Annals of Statistics

Case-control survival analysis with a general semiparametric shared frailty model: A pseudo full likelihood approach

Malka Gorfine, David M. Zucker, and Li Hsu

Full-text: Open access

Abstract

In this work we deal with correlated failure time (age at onset) data arising from population-based, case-control studies, where case and control probands are selected by population-based sampling and an array of risk factor measures is collected for both cases and controls and their relatives. Parameters of interest are effects of risk factors on the failure time hazard function and within-family dependencies among failure times after adjusting for the risk factors. Due to the retrospective sampling scheme, large sample theory for existing methods has not been established. We develop a novel technique for estimating the parameters of interest under a general semiparametric shared frailty model. We also present a simple, easily computed, and noniterative nonparametric estimator for the cumulative baseline hazard function. We provide rigorous large sample theory for the proposed method. We also present simulation results and a real data example for illustrating the utility of the proposed method.

Article information

Source
Ann. Statist. Volume 37, Number 3 (2009), 1489-1517.

Dates
First available in Project Euclid: 10 April 2009

Permanent link to this document
http://projecteuclid.org/euclid.aos/1239369029

Digital Object Identifier
doi:10.1214/08-AOS615

Mathematical Reviews number (MathSciNet)
MR2509081

Zentralblatt MATH identifier
1160.62088

Subjects
Primary: 62N01: Censored data models 62N02: Estimation 62H12: Estimation

Keywords
Case-control study correlated failure times family study frailty model multivariate survival model

Citation

Gorfine, Malka; Zucker, David M.; Hsu, Li. Case-control survival analysis with a general semiparametric shared frailty model: A pseudo full likelihood approach. Ann. Statist. 37 (2009), no. 3, 1489--1517. doi:10.1214/08-AOS615. http://projecteuclid.org/euclid.aos/1239369029.


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