The Annals of Statistics

The Adaptive Biased Coin Design for Sequential Experiments

L. J. Wei

Full-text: Open access

Abstract

In comparing two treatments, eligible subjects come to the experiment sequentially and must be treated at once. To reduce experimental bias and to increase the precision of inference about treatment effects, the adaptive biased coin design, which offers a compromise between perfect balance and complete randomization, is proposed and analyzed. This new design has the property that it forces a small-sized experiment to be balanced, but tends toward the complete randomization scheme as the size of the experiment increases.

Article information

Source
Ann. Statist., Volume 6, Number 1 (1978), 92-100.

Dates
First available in Project Euclid: 12 April 2007

Permanent link to this document
https://projecteuclid.org/euclid.aos/1176344068

Digital Object Identifier
doi:10.1214/aos/1176344068

Mathematical Reviews number (MathSciNet)
MR471205

Zentralblatt MATH identifier
0374.62075

JSTOR
links.jstor.org

Subjects
Primary: 62L05: Sequential design
Secondary: 60K30: Applications (congestion, allocation, storage, traffic, etc.) [See also 90Bxx]

Keywords
Sequential experiment biased coin design experimental bias balance randomization clinical trial

Citation

Wei, L. J. The Adaptive Biased Coin Design for Sequential Experiments. Ann. Statist. 6 (1978), no. 1, 92--100. doi:10.1214/aos/1176344068. https://projecteuclid.org/euclid.aos/1176344068


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