The Annals of Applied Statistics
- Ann. Appl. Stat.
- Volume 11, Number 4 (2017), 2200-2221.
Empirical Bayesian analysis of simultaneous changepoints in multiple data sequences
Copy number variations in cancer cells and volatility fluctuations in stock prices are commonly manifested as changepoints occurring at the same positions across related data sequences. We introduce a Bayesian modeling framework, BASIC, that employs a changepoint prior to capture the co-occurrence tendency in data of this type. We design efficient algorithms to sample from and maximize over the BASIC changepoint posterior and develop a Monte Carlo expectation-maximization procedure to select prior hyperparameters in an empirical Bayes fashion. We use the resulting BASIC framework to analyze DNA copy number variations in the NCI-60 cancer cell lines and to identify important events that affected the price volatility of S&P 500 stocks from 2000 to 2009.
Ann. Appl. Stat., Volume 11, Number 4 (2017), 2200-2221.
Received: July 2016
Revised: April 2017
First available in Project Euclid: 28 December 2017
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Fan, Zhou; Mackey, Lester. Empirical Bayesian analysis of simultaneous changepoints in multiple data sequences. Ann. Appl. Stat. 11 (2017), no. 4, 2200--2221. doi:10.1214/17-AOAS1075. https://projecteuclid.org/euclid.aoas/1514430283
- Supplementary Appendices. The Supplementary Appendices [Fan and Mackey (2017)] contain the following additional materials, as referenced in the main text: Description of common likelihood models and associated priors, details of inference procedures, comparison of MCMC sampler with naïve Gibbs sampling, and additional details of copy number analysis for the NCI-60 cell lines.