The Annals of Applied Statistics

Topological inference for EEG and MEG

James M. Kilner and Karl J. Friston

Full-text: Open access

Abstract

Neuroimaging produces data that are continuous in one or more dimensions. This calls for an inference framework that can handle data that approximate functions of space, for example, anatomical images, time–frequency maps and distributed source reconstructions of electromagnetic recordings over time. Statistical parametric mapping (SPM) is the standard framework for whole-brain inference in neuroimaging: SPM uses random field theory to furnish p-values that are adjusted to control family-wise error or false discovery rates, when making topological inferences over large volumes of space. Random field theory regards data as realizations of a continuous process in one or more dimensions. This contrasts with classical approaches like the Bonferroni correction, which consider images as collections of discrete samples with no continuity properties (i.e., the probabilistic behavior at one point in the image does not depend on other points). Here, we illustrate how random field theory can be applied to data that vary as a function of time, space or frequency. We emphasize how topological inference of this sort is invariant to the geometry of the manifolds on which data are sampled. This is particularly useful in electromagnetic studies that often deal with very smooth data on scalp or cortical meshes. This application illustrates the versatility and simplicity of random field theory and the seminal contributions of Keith Worsley (1951–2009), a key architect of topological inference.

Article information

Source
Ann. Appl. Stat. Volume 4, Number 3 (2010), 1272-1290.

Dates
First available in Project Euclid: 18 October 2010

Permanent link to this document
https://projecteuclid.org/euclid.aoas/1287409373

Digital Object Identifier
doi:10.1214/10-AOAS337

Mathematical Reviews number (MathSciNet)
MR2758328

Zentralblatt MATH identifier
1202.62154

Keywords
Random field theory topological inference statistical parametric mapping

Citation

Kilner, James M.; Friston, Karl J. Topological inference for EEG and MEG. Ann. Appl. Stat. 4 (2010), no. 3, 1272--1290. doi:10.1214/10-AOAS337. https://projecteuclid.org/euclid.aoas/1287409373.


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