The Annals of Applied Statistics

Analysis of Minnesota colon and rectum cancer point patterns with spatial and nonspatial covariate information

Shengde Liang, Bradley P. Carlin, and Alan E. Gelfand

Full-text: Open access

Abstract

Colon and rectum cancer share many risk factors, and are often tabulated together as “colorectal cancer” in published summaries. However, recent work indicating that exercise, diet, and family history may have differential impacts on the two cancers encourages analyzing them separately, so that corresponding public health interventions can be more efficiently targeted. We analyze colon and rectum cancer data from the Minnesota Cancer Surveillance System from 1998–2002 over the 16-county Twin Cities (Minneapolis–St. Paul) metro and exurban area. The data consist of two marked point patterns, meaning that any statistical model must account for randomness in the observed locations, and expected positive association between the two cancer patterns. Our model extends marked spatial point pattern analysis in the context of a log Gaussian Cox process to accommodate spatially referenced covariates (local poverty rate and location within the metro area), individual-level risk factors (patient age and cancer stage), and related interactions. We obtain smoothed maps of marginal log-relative intensity surfaces for colon and rectum cancer, and uncover significant age and stage differences between the two groups. This encourages more aggressive colon cancer screening in the inner Twin Cities and their southern and western exurbs, where our model indicates higher colon cancer relative intensity.

Article information

Source
Ann. Appl. Stat., Volume 3, Number 3 (2009), 943-962.

Dates
First available in Project Euclid: 5 October 2009

Permanent link to this document
https://projecteuclid.org/euclid.aoas/1254773273

Digital Object Identifier
doi:10.1214/09-AOAS240

Mathematical Reviews number (MathSciNet)
MR2750381

Zentralblatt MATH identifier
1196.62143

Keywords
Colon cancer log Gaussian Cox process (LGCP) rectum cancer spatial point process

Citation

Liang, Shengde; Carlin, Bradley P.; Gelfand, Alan E. Analysis of Minnesota colon and rectum cancer point patterns with spatial and nonspatial covariate information. Ann. Appl. Stat. 3 (2009), no. 3, 943--962. doi:10.1214/09-AOAS240. https://projecteuclid.org/euclid.aoas/1254773273


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