Annals of Applied Statistics

Nonparametric spectral analysis with applications to seizure characterization using EEG time series

Li Qin and Yuedong Wang

Full-text: Open access

Abstract

Understanding the seizure initiation process and its propagation pattern(s) is a critical task in epilepsy research. Characteristics of the pre-seizure electroencephalograms (EEGs) such as oscillating powers and high-frequency activities are believed to be indicative of the seizure onset and spread patterns. In this article, we analyze epileptic EEG time series using nonparametric spectral estimation methods to extract information on seizure-specific power and characteristic frequency [or frequency band(s)]. Because the EEGs may become nonstationary before seizure events, we develop methods for both stationary and local stationary processes. Based on penalized Whittle likelihood, we propose a direct generalized maximum likelihood (GML) and generalized approximate cross-validation (GACV) methods to estimate smoothing parameters in both smoothing spline spectrum estimation of a stationary process and smoothing spline ANOVA time-varying spectrum estimation of a locally stationary process. We also propose permutation methods to test if a locally stationary process is stationary. Extensive simulations indicate that the proposed direct methods, especially the direct GML, are stable and perform better than other existing methods. We apply the proposed methods to the intracranial electroencephalograms (IEEGs) of an epileptic patient to gain insights into the seizure generation process.

Article information

Source
Ann. Appl. Stat., Volume 2, Number 4 (2008), 1432-1451.

Dates
First available in Project Euclid: 8 January 2009

Permanent link to this document
https://projecteuclid.org/euclid.aoas/1231424217

Digital Object Identifier
doi:10.1214/08-AOAS185

Mathematical Reviews number (MathSciNet)
MR2655666

Zentralblatt MATH identifier
1156.62059

Keywords
EEG epilepsy GACV GML locally stationary process permutation test smoothing parameter smoothing spline SS ANOVA

Citation

Qin, Li; Wang, Yuedong. Nonparametric spectral analysis with applications to seizure characterization using EEG time series. Ann. Appl. Stat. 2 (2008), no. 4, 1432--1451. doi:10.1214/08-AOAS185. https://projecteuclid.org/euclid.aoas/1231424217


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