Abstract and Applied Analysis

Stokes Efficiency of Molecular Motor-Cargo Systems

Hongyun Wang and Hong Zhou

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Abstract

A molecular motor utilizes chemical free energy to generate a unidirectional motion through the viscous fluid. In many experimental settings and biological settings, a molecular motor is elastically linked to a cargo. The stochastic motion of a molecular motor-cargo system is governed by a set of Langevin equations, each corresponding to an individual chemical occupancy state. The change of chemical occupancy state is modeled by a continuous time discrete space Markov process. The probability density of a motor-cargo system is governed by a two-dimensional Fokker-Planck equation. The operation of a molecular motor is dominated by high viscous friction and large thermal fluctuations from surrounding fluid. The instantaneous velocity of a molecular motor is highly stochastic: the past velocity is quickly damped by the viscous friction and the new velocity is quickly excited by bombardments of surrounding fluid molecules. Thus, the theory for macroscopic motors should not be applied directly to molecular motors without close examination. In particular, a molecular motor behaves differently working against a viscous drag than working against a conservative force. The Stokes efficiency was introduced to measure how efficiently a motor uses chemical free energy to drive against viscous drag. For a motor without cargo, it was proved that the Stokes efficiency is bounded by 100% [H. Wang and G. Oster, (2002)]. Here, we present a proof for the general motor-cargo system.

Article information

Source
Abstr. Appl. Anal., Volume 2008 (2008), Article ID 241736, 13 pages.

Dates
First available in Project Euclid: 9 September 2008

Permanent link to this document
https://projecteuclid.org/euclid.aaa/1220969170

Digital Object Identifier
doi:10.1155/2008/241736

Mathematical Reviews number (MathSciNet)
MR2407283

Zentralblatt MATH identifier
1141.92044

Citation

Wang, Hongyun; Zhou, Hong. Stokes Efficiency of Molecular Motor-Cargo Systems. Abstr. Appl. Anal. 2008 (2008), Article ID 241736, 13 pages. doi:10.1155/2008/241736. https://projecteuclid.org/euclid.aaa/1220969170


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