Statistical Science

Comment: Microarrays, Empirical Bayes and the Two-Groups Model

Carl N. Morris

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Abstract

Brad Efron’s paper has inspired a return to the ideas behind Bayes, frequency and empirical Bayes. The latter preferably would not be limited to exchangeable models for the data and hyperparameters. Parallels are revealed between microarray analyses and profiling of hospitals, with advances suggesting more decision modeling for gene identification also. Then good multilevel and empirical Bayes models for random effects should be sought when regression toward the mean is anticipated.

Article information

Source
Statist. Sci. Volume 23, Number 1 (2008), 34-40.

Dates
First available in Project Euclid: 7 July 2008

Permanent link to this document
http://projecteuclid.org/euclid.ss/1215441279

Digital Object Identifier
doi:10.1214/08-STS236D

Mathematical Reviews number (MathSciNet)
MR2523936

Zentralblatt MATH identifier
1327.62049

Keywords
Bayes frequency interval estimation exchangeable general model random effects

Citation

Morris, Carl N. Comment: Microarrays, Empirical Bayes and the Two-Groups Model. Statist. Sci. 23 (2008), no. 1, 34--40. doi:10.1214/08-STS236D. http://projecteuclid.org/euclid.ss/1215441279.


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References

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The Institute of Mathematical Statistics

Statistical Science

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