Intensity-dependent normalization in microarray analysis: a note of concern

Mei-Ling Ting Lee; George A. Whitmore

doi:10.3150/bj/1106314844

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Home > Journals > Bernoulli > Volume 10 > Issue 6 > Article

December 2004 Intensity-dependent normalization in microarray analysis: a note of concern

Mei-Ling Ting Lee, George A. Whitmore

Author Affiliations +

Mei-Ling Ting Lee,¹ George A. Whitmore²
¹Channing Laboratory, HMS/BWH
²Faculty of Management, McGill University

Bernoulli 10(6): 943-949 (December 2004). DOI: 10.3150/bj/1106314844

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Abstract

We discuss the concern that intensity-dependent normalization can give biased estimates of differential expression and, therefore, can misclassify some moderately important genes as unexpressed.

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Mei-Ling Ting Lee. George A. Whitmore. "Intensity-dependent normalization in microarray analysis: a note of concern." Bernoulli 10 (6) 943 - 949, December 2004. https://doi.org/10.3150/bj/1106314844

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Published: December 2004

First available in Project Euclid: 21 January 2005

zbMATH: 1064.62111

MathSciNet: MR2108037

Digital Object Identifier: 10.3150/bj/1106314844

Keywords: gene expression , intensity dependence , MA-plot , microarray , normalization

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Bernoulli

Vol.10 • No. 6 • December 2004

Bernoulli Society for Mathematical Statistics and Probability

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Mei-Ling Ting Lee, George A. Whitmore "Intensity-dependent normalization in microarray analysis: a note of concern," Bernoulli, Bernoulli 10(6), 943-949, (December 2004)

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