The Annals of Statistics
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Optimal discrimination designs

Holger Dette and Stefanie Titoff

Source: Ann. Statist. Volume 37, Number 4 (2009), 2056-2082.

Abstract

We consider the problem of constructing optimal designs for model discrimination between competing regression models. Various new properties of optimal designs with respect to the popular T-optimality criterion are derived, which in many circumstances allow an explicit determination of T-optimal designs. It is also demonstrated, that in nested linear models the number of support points of T-optimal designs is usually too small to estimate all parameters in the extended model. In many cases T-optimal designs are usually not unique, and in this situation we give a characterization of all T-optimal designs. Finally, T-optimal designs are compared with optimal discriminating designs with respect to alternative criteria by means of a small simulation study.

Primary Subjects: 62K05, 41A50
Keywords: Model discrimination; optimal design; T-optimality; D_s-optimality; nonlinear approximation

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Permanent link to this document: http://projecteuclid.org/euclid.aos/1245332840
Digital Object Identifier: doi:10.1214/08-AOS635
Mathematical Reviews number (MathSciNet): MR2533479

References

[1] Achiezer, N. I. (1956). Theory of Approximation. Ungar, New York.
[2] Atkinson, A. C. and Donev, A. N. (1992). Optimum Experimental Designs. Clarendon Press, Oxford.
[3] Atkinson, A. C. and Fedorov, V. V. (1975). The design of experiments for discriminating between two rival models. Biometrika 62 57–70.
Mathematical Reviews (MathSciNet): MR370955
Digital Object Identifier: doi:10.1093/biomet/62.1.57
[4] Atkinson, A. C. and Fedorov, V. V. (1975). Optimal design: Experiments for discriminating between several models. Biometrika 62 289–303.
Mathematical Reviews (MathSciNet): MR381163
[5] Box, G. E. P. and Hill, W. J. (1967). Discrimination among mechanistic models. Technometrics 9 57–71.
Mathematical Reviews (MathSciNet): MR223048
Digital Object Identifier: doi:10.2307/1266318
[6] Biedermann, S., Dette, H. and Pepelysheff, A. (2007). Optimal discrimination designs for exponential regression models. J. Statist. Plann. Inference 137 2579–2592.
Mathematical Reviews (MathSciNet): MR2326111
Digital Object Identifier: doi:10.1016/j.jspi.2006.03.015
[7] Braess, D. (1986). Nonlinear Approximation Theory. Springer, Berlin.
Mathematical Reviews (MathSciNet): MR866667
[8] Clyde, M. and Chaloner, K. (1996). The equivalence of constrained and weighted designs in multiple objective design problems. J. Amer. Statist. Assoc. 91 1236–1244.
Mathematical Reviews (MathSciNet): MR1424621
Digital Object Identifier: doi:10.2307/2291742
[9] Cook, D. and Wong, W. K. (1994). On the equivalence of constrained and weighted designs in multiple objective design problems. J. Amer. Statist. Assoc. 89 687–692.
[10] Dette, H. (1994). Discrimination designs for polynomial regression on a compact interval. Ann. Statist. 22 890–904.
Mathematical Reviews (MathSciNet): MR1292546
Digital Object Identifier: doi:10.1214/aos/1176325501
Project Euclid: euclid.aos/1176325501
[11] Dette, H. (1997). Designing experiments with respect to “standardized” optimality criteria. J. Roy. Statist. Soc. Ser. B 59 97–110.
Mathematical Reviews (MathSciNet): MR1436556
Digital Object Identifier: doi:10.1111/1467-9868.00056
[12] Dette, H. and Haller, G. (1998). Optimal discriminating designs for Fourier regression. Ann. Statist. 26 1496–1521.
Mathematical Reviews (MathSciNet): MR1647689
Digital Object Identifier: doi:10.1214/aos/1024691251
Project Euclid: euclid.aos/1024691251
[13] Dette, H. and Neugebauer, H. M. (1996). Bayesian optimal one point designs for one parameter nonlinear models. J. Statist. Plann. Inference 52 17–31.
Mathematical Reviews (MathSciNet): MR1391681
Digital Object Identifier: doi:10.1016/0378-3758(95)00104-2
[14] Dette, H. and Neugebauer, H. M. (1997). Bayesian D-optimal designs for exponential regression models. J. Statist. Plann. Inference 60 331–349.
Mathematical Reviews (MathSciNet): MR1456635
Digital Object Identifier: doi:10.1016/S0378-3758(96)00131-0
[15] Dette, H., Melas, V. B. and Pepelysheff, A. (2006). Local c- and E-optimal designs for exponential regression models. Ann. Inst. Statist. Math. 58 407–426.
Mathematical Reviews (MathSciNet): MR2239547
Digital Object Identifier: doi:10.1007/s10463-006-0031-2
[16] Fedorov, V. V. (1972). Theory of Optimal Experiments. Academic Press, New York, London.
Mathematical Reviews (MathSciNet): MR403103
[17] Hunter, W. G. and Reiner, A. M. (1965). Designs for discriminating between two rival models. Technometrics 7 307–323.
Mathematical Reviews (MathSciNet): MR192615
Digital Object Identifier: doi:10.2307/1266591
[18] Hill, P. D. (1978). A review of experimental design procedures for regression model discrimination. Technometrics 20 15–21.
[19] Imhof, L. A. and Studden, W. J. (2001). E-optimal designs for rational models. Ann. Statist. 29 763–783.
Mathematical Reviews (MathSciNet): MR1865340
Digital Object Identifier: doi:10.1214/aos/1009210689
Project Euclid: euclid.aos/1009210689
[20] Karlin, S. and Studden, W. J. (1966). Tchebycheff Systems: With Applications in Analysis and Statistics. Wiley, New York.
Mathematical Reviews (MathSciNet): MR204922
[21] Kiefer, J. (1974). General equivalence theory for optimum designs (approximate theory). Ann. Statist. 2 849–879.
Mathematical Reviews (MathSciNet): MR356386
Digital Object Identifier: doi:10.1214/aos/1176342810
Project Euclid: euclid.aos/1176342810
[22] Kiefer, J. and Wolfowitz, J. (1965). On a theorem of Hoel and Levine on extrapolation Designs. Ann. Math. Statist. 36 1627–1655.
Mathematical Reviews (MathSciNet): MR185769
Digital Object Identifier: doi:10.1214/aoms/1177699793
Project Euclid: euclid.aoms/1177699793
[23] Läuter, E. (1974). Experimental design in a class of models. Math. Operationsforsch. Statist. 5 379–398.
Mathematical Reviews (MathSciNet): MR440812
[24] López-Fidalgo, J., Tommasi, C. and Trandafir, P. C. (2007). An optimal experimental design criterion for discriminating between nonnormal models. J. Roy. Statist. Soc. Ser. B 69 231–242.
[25] Müller, C. H. and Pázman, A. (1998). Applications of necessary and sufficient conditions for maximin efficient designs. Metrika 48 1–19.
[26] Pázman, A. (1986). Foundations of Optimum Experimental Design. D. Reidel Publishing Company, Dordrect, Holland.
[27] Pukelsheim, F. (1993). Optimal Design of Experiments. Wiley, New York.
Mathematical Reviews (MathSciNet): MR1211416
[28] Pukelsheim, F. and Studden, W. J. (1993). E-optimal designs for polynomial regression. Ann. Statist. 21 402–415.
Mathematical Reviews (MathSciNet): MR1212184
Digital Object Identifier: doi:10.1214/aos/1176349033
Project Euclid: euclid.aos/1176349033
[29] Rowland, M. (1995). Clinical Pharmacokinetics: Concepts and Applications. Williams and Wilkins, Baltimore.
[30] Rice, J. (1969). The Approximation of Functions. 1, 2. Addison Wesley.
Mathematical Reviews (MathSciNet): MR244675
[31] Shargel, L. and Yu, A. B. (1993). Applied biopharmaceutics and pharmacokinetics. Appleton and Lange, US.
[32] Silvey, S. D. (1980). Optimal Design. Chapman and Hall, London.
Mathematical Reviews (MathSciNet): MR606742
[33] Spruill, M. C. (1990). Good designs for testing the degree of a polynomial mean. Sankhya, Ser. B 52 67–74.
Mathematical Reviews (MathSciNet): MR1178893
[34] Stigler, S. (1971). Optimal experimental design for polynomial regression. J. Amer. Statist. Assoc. 66 311–318.
[35] Song, D. and Wong, W. K. (1999). On the construction of Grm-optimal designs. Statist. Sinica 9 263–272.
Mathematical Reviews (MathSciNet): MR1678893
[36] Studden, W. J. (1968). Optimal designs on Tchebycheff points. Ann. Math. Statist. 39 1435–1447.
Mathematical Reviews (MathSciNet): MR231497
Project Euclid: euclid.aoms/1177698123
[37] Studden, W. J. (1980). Ds-optimal designs for polynomial regression using continued fractions. Ann. Statist. 8 1132–1141.
Mathematical Reviews (MathSciNet): MR585711
Digital Object Identifier: doi:10.1214/aos/1176345150
Project Euclid: euclid.aos/1176345150
[38] Studden, W. J. (1982). Some robust-type D-optimal designs in polynomial regression. J. Amer. Statist. Assoc. 77 916–921.
Mathematical Reviews (MathSciNet): MR686418
Digital Object Identifier: doi:10.2307/2287327
[39] Ucinski, D. and Bogacka, B. (2005). T-optimum designs for discrimination between two multiresponse dynamic models. J. Roy. Statist. Soc. Ser. B 67 3–18.
Mathematical Reviews (MathSciNet): MR2136636
Digital Object Identifier: doi:10.1111/j.1467-9868.2005.00485.x
[40] Waterhouse, T. H., Woods, D. C., Eccleston, J. A. and Lewis, S. M. (2008). Design selection criteria for discrimination/estimation for nested models and a binomial response. J. Statist. Plann. Inference 138 132–144.
Mathematical Reviews (MathSciNet): MR2369620
Digital Object Identifier: doi:10.1016/j.jspi.2007.05.017
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