The Annals of Applied Statistics

Network inference and biological dynamics

Chris. J. Oates and Sach Mukherjee

Full-text: Open access

Abstract

Network inference approaches are now widely used in biological applications to probe regulatory relationships between molecular components such as genes or proteins. Many methods have been proposed for this setting, but the connections and differences between their statistical formulations have received less attention. In this paper, we show how a broad class of statistical network inference methods, including a number of existing approaches, can be described in terms of variable selection for the linear model. This reveals some subtle but important differences between the methods, including the treatment of time intervals in discretely observed data. In developing a general formulation, we also explore the relationship between single-cell stochastic dynamics and network inference on averages over cells. This clarifies the link between biochemical networks as they operate at the cellular level and network inference as carried out on data that are averages over populations of cells. We present empirical results, comparing thirty-two network inference methods that are instances of the general formulation we describe, using two published dynamical models. Our investigation sheds light on the applicability and limitations of network inference and provides guidance for practitioners and suggestions for experimental design.

Article information

Source
Ann. Appl. Stat. Volume 6, Number 3 (2012), 1209-1235.

Dates
First available in Project Euclid: 31 August 2012

Permanent link to this document
http://projecteuclid.org/euclid.aoas/1346418580

Digital Object Identifier
doi:10.1214/11-AOAS532

Mathematical Reviews number (MathSciNet)
MR3012527

Zentralblatt MATH identifier
1257.62108

Keywords
Network inference biological dynamics variable selection

Citation

Oates, Chris. J.; Mukherjee, Sach. Network inference and biological dynamics. Ann. Appl. Stat. 6 (2012), no. 3, 1209--1235. doi:10.1214/11-AOAS532. http://projecteuclid.org/euclid.aoas/1346418580.


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Supplemental materials

  • Supplementary material: Additional materials. This supplement provides the dynamical systems used in this paper and accompanying MATLAB R2010a scripts, derivations and additional figures SFigures 1–16.