Advances in Applied Probability

Selective sweep and the size of the hitchhiking set

Leocard Stephanie

Source: Adv. in Appl. Probab. Volume 41, Number 3 (2009), 731-764.

Abstract

Just after the fixation of an advantageous allele in the population (this spread is called a selective sweep), the neutral genes close to the site under selection tend to have the same ancestor as the gene under selection. However, some recombinations may occur during the selective sweep and break the link, which reduces the number of hitchhiking alleles. We consider a large selection coefficient α and extend the results of Etheridge, Pfaffelhuber and Wakolbinger (2006) and the work of Pfaffelhuber and Studeny (2007) about genetic hitchhiking, where the recombination rate scales with α/log α. We first describe the genealogy at an arbitrary number of partially linked neutral loci, with an order of accuracy of 𝓞(1/(log α)2) in total variation. Then, we use this framework to obtain an approximate distribution for the size of the hitchhiking set at the end of the selective sweep, with the same accuracy.

Primary Subjects: 92D15
Secondary Subjects: 60J80, 60J85, 60K37, 92D10
Keywords: Coalescence; recombination; selective sweep; hitchhiking allele

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Links and Identifiers

Permanent link to this document: http://projecteuclid.org/euclid.aap/1253281062
Digital Object Identifier: doi:10.1239/aap/1253281062
Zentralblatt MATH identifier: 05625066

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